Target name

Q9JI35: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9JI35
GRCP SARfari Variant Name cavHRH3_1189
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
Entrez Gene (Gene ID) 100135541
BindingDB Q9JI35

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.95 0.92 0.94 0.94 0.98 0.87 Download
FP4 fingerprints 0.920 0.930 0.920 0.920 0.970 0.850 Download
MACCS fingerprints 0.890 0.790 0.840 0.850 0.920 0.680 Download
Daylight fingerprints 0.850 0.820 0.840 0.840 0.890 0.680 Download
ECFP2 fingerprints 0.940 0.900 0.920 0.920 0.970 0.840 Download
ECFP4 fingerprints 0.960 0.940 0.950 0.950 0.990 0.900 Download
ECFP6 fingerprints 0.940 0.970 0.950 0.950 0.990 0.900 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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