Target name

Q9NPC1: Leukotriene B4 receptor 2


  Protein function

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

  Database links

Uniprot primary ID Q9NPC1
GRCP SARfari Variant Name hLTB4R2_268
PDB ID
DrugBank ID
BioGrid ID 121143
GuidetoPHARMACOLOGY ID 268
PharmGKB ID PA134910672
KEGG ID hsa:56413
Entrez Gene (Gene ID) 56413
BindingDB Q9NPC1

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.9 0.87 0.89 0.89 0.94 0.78 Download
FP4 fingerprints 0.930 0.820 0.880 0.880 0.930 0.760 Download
MACCS fingerprints 0.880 0.830 0.860 0.860 0.900 0.710 Download
Daylight fingerprints 0.890 0.820 0.860 0.860 0.910 0.720 Download
ECFP2 fingerprints 0.940 0.860 0.900 0.900 0.970 0.790 Download
ECFP4 fingerprints 0.950 0.880 0.910 0.920 0.970 0.830 Download
ECFP6 fingerprints 0.940 0.890 0.920 0.920 0.970 0.830 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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