Target name

Q9NS75: Cysteinyl leukotriene receptor 2


  Protein function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

  Database links

Uniprot primary ID Q9NS75
GRCP SARfari Variant Name hCYSLTR2_274
PDB ID
DrugBank ID DB00716
BioGrid ID 121371
GuidetoPHARMACOLOGY ID 270
PharmGKB ID PA38518
KEGG ID hsa:57105
Entrez Gene (Gene ID) 57105
BindingDB Q9NS75

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.94 0.93 0.93 0.93 0.97 0.87 Download
FP4 fingerprints 0.900 0.870 0.890 0.890 0.950 0.770 Download
MACCS fingerprints 0.930 0.900 0.920 0.920 0.960 0.830 Download
Daylight fingerprints 0.910 0.820 0.860 0.870 0.910 0.730 Download
ECFP2 fingerprints 0.930 0.930 0.930 0.930 0.970 0.860 Download
ECFP4 fingerprints 0.980 0.950 0.960 0.960 0.980 0.920 Download
ECFP6 fingerprints 0.960 0.950 0.960 0.960 0.980 0.910 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2015 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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