Target name

Q9QYN8: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

  Database links

Uniprot primary ID Q9QYN8
GRCP SARfari Variant Name rHRH3_1207
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 264
PharmGKB ID
KEGG ID rno:85268
Entrez Gene (Gene ID) 85268
BindingDB Q9QYN8

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.86 0.84 0.85 0.85 0.93 0.7 Download
FP4 fingerprints 0.880 0.740 0.810 0.820 0.890 0.630 Download
MACCS fingerprints 0.830 0.790 0.810 0.820 0.900 0.620 Download
Daylight fingerprints 0.660 0.830 0.740 0.720 0.820 0.490 Download
ECFP2 fingerprints 0.940 0.920 0.930 0.930 0.970 0.860 Download
ECFP4 fingerprints 0.940 0.960 0.950 0.950 0.980 0.900 Download
ECFP6 fingerprints 0.940 0.970 0.950 0.950 0.980 0.900 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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