Target name

Q9Y271: Cysteinyl leukotriene receptor 1


  Protein function

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

  Database links

Uniprot primary ID Q9Y271
GRCP SARfari Variant Name hCYSLTR1_287
PDB ID
DrugBank ID DB01411 DB00471 DB00716 DB00549 DB00587
BioGrid ID 116014
GuidetoPHARMACOLOGY ID 269
PharmGKB ID PA38453
KEGG ID hsa:10800
Entrez Gene (Gene ID) 10800
BindingDB Q9Y271

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.97 0.93 0.95 0.95 0.97 0.9 Download
FP4 fingerprints 0.930 0.850 0.890 0.900 0.950 0.790 Download
MACCS fingerprints 0.930 0.860 0.900 0.900 0.940 0.790 Download
Daylight fingerprints 0.890 0.920 0.900 0.900 0.960 0.810 Download
ECFP2 fingerprints 0.970 0.910 0.940 0.940 0.980 0.890 Download
ECFP4 fingerprints 0.990 0.950 0.970 0.970 0.990 0.940 Download
ECFP6 fingerprints 0.970 0.960 0.960 0.960 0.990 0.930 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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