Target name

Q9Y5N1: Histamine H3 receptor


  Protein function

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform

  Database links

Uniprot primary ID Q9Y5N1
GRCP SARfari Variant Name hHRH3_290
PDB ID
DrugBank ID DB00370 DB06698 DB00667
BioGrid ID 116416
GuidetoPHARMACOLOGY ID 264
PharmGKB ID PA29458
KEGG ID hsa:11255
Entrez Gene (Gene ID) 11255
BindingDB Q9Y5N1

  Model Performance Metrics

Fingerprint type Sensitivity Specificity Accuracy F1-score AUC Matthews_corrcoef Download model
FP2 fingerprints 0.87 0.79 0.83 0.84 0.91 0.66 Download
FP4 fingerprints 0.840 0.740 0.790 0.800 0.870 0.580 Download
MACCS fingerprints 0.810 0.700 0.750 0.770 0.840 0.510 Download
Daylight fingerprints 0.660 0.780 0.720 0.700 0.790 0.440 Download
ECFP2 fingerprints 0.930 0.850 0.890 0.890 0.960 0.780 Download
ECFP4 fingerprints 0.940 0.930 0.930 0.940 0.980 0.870 Download
ECFP6 fingerprints 0.920 0.940 0.930 0.930 0.980 0.860 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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